TITLE:
Clinic Pathological Profile of Neuroblastoma, Our Experience at Tertiary Care Hospital; Government Medical College Hospital Srinagar J & K
AUTHORS:
Zahida Akhter, Shahnawaz Mansoor Shah, Perveez Ahmad Malik, Showkat Ahmad Kakroo
KEYWORDS:
Child Hood Malignancies, Neuroblastoma
JOURNAL NAME:
Surgical Science,
Vol.7 No.8,
August
29,
2016
ABSTRACT: Introduction: Pediatric tumors account for a small proportion of all
cancers; amongst them neuroblastoma is the most common solid tumor as well as
malignant tumor. They have varied clinical presentation.
Recent advances in diagnostic methods and multidisciplinary treatment approach
have resulted in early diagnosis, treatment, better prognosis and survival.
Aims and Objectives: To study the clinical profile, histopathology, grading and
correlate that with clinical diagnosis, efficacy of various investigations for
early diagnosis, and management of neuroblastoma in our hospital. Material and
Methods: A total of nine patients of neuroblastoma were studied from May 2013
to January 2015. All the nine patients were operated. Neuroblastoma was staged
according to the International Neuroblastoma Staging system. Follow-up was
carried in all the patients. Results: Two patients in our study were Stage 1,
two were Stage 2A and 5 patients were Stage 4S.
In Stage 1, pre-operative chemotherapy was not given. Tumor was excised in toto. Post-operatively, no adjuvant therapy was given. Patients are alive till
date. In Stage 2A, patients were operated and received post-operative
chemotherapy. One patient is alive and disease-free. Other patient died in
post-op. period while on chemotherapy. Patients in Stage 4S were operated after
receiving pre-op radiotherapy of 500 - 1000 radians and adjuvant chemotherapy.
One patient expired in follow-up while four patients are still alive. We have
achieved 100% survival rate in Stage 1, 50% in Stage 2 and 80% in Stage 4S.