TITLE:
Study of Antiparasitic and Cytotoxicity of the Aqueous, the 80% Methanol Extract and Its Fractions, and the Acute Toxicity of the Aqueous Extract of Brucea sumatrana (Simaroubaceae) Leaves Collected in Mai-Ndombe, Democratic Republic of Congo
AUTHORS:
M. Tshodi Ehata, S. Nsaka Lumpu, C. Kikweta Munduku, O. Kambu Kabangu, P. Cos, L. Maes, S. Apers, A. J. Vlietinck, L. Pieters, R. Cimanga Kanyanga
KEYWORDS:
Brucea sumatrana, Simaroubaceae, Leaves, Extracts, Antiprotozoal Activity, Cyto-toxic Activity, Acute Toxicity
JOURNAL NAME:
Chinese Medicine,
Vol.7 No.3,
August
26,
2016
ABSTRACT: Results from the in
vitro evaluation of the antiparasitaire activity of the aqueous extract,
the 80% methanol extract and its fractions from the leaves of Brucea sumatrana against Trypanosoma brucei brucei, T. cruzi, Leishmania infantum, the multidrug-resistant K1 and
chloroquine-sensitive NF54 strains of Plasmodium
falciparum indicated that all samples from the leaves extract presented
interesting antiparasitaire activity at different extents. The 80% methanol
extract, its chloroform acid, petroleum ether and 80% methanol soluble
fractions and the aqueous extract exhibited strong activity against Trypanosoma b. brucei, T. cruzi, L. infantum and the multidrug-resistant K1 strain of P. falciparum with IC50 values from P. falciparum with IC50 values ranging from 50)
50 was estimated to be greater than 5 g/kg. In addition, it
did not significantly modify the concentration levels of some evaluated
biochemical and hematological
parameters in treated rats. These results constitute a scientific validation
supporting and justifying the traditional use of the leaves of B. sumatrana for the treatment of
malaria, sleeping sickness and at some extent Chagas disease.