TITLE:
Gastric Collision Tumor of Adenocarcinoma and MALT Lymphoma: A Rare Coincidence or Proof of H. pylori Incrimination?
AUTHORS:
Haithem Zaafouri, Anis Hasnaoui, Raja Jouini, Dhafer Haddad, Ahmed Bouhafa, Anis Ben Maamer
KEYWORDS:
Collision Tumor, Gastric, Lymphoma, Adenocarcinoma, Helicobacter pylori
JOURNAL NAME:
Surgical Science,
Vol.7 No.8,
August
22,
2016
ABSTRACT: Collision tumors of adenocarcinoma and MALT (Mucosa-associated lymphoid
tissue) lymphoma are often rare findings of resection specimens of gastric
carcinomas. The fact that these two histological lesions are contiguous may
suggest a common oncogene. As it is widely known, Helicobacter pylori (H. pylori)
plays a leading role in gastric oncogenesis. Could it be responsible for these
tumors? As of today, the exact mechanism is still unclear. However, some
histological findings may suggest that H.
pylori promotes the formation of MALT lymphoma which increases the risk of
carcinomatous changes. Prognosis of collision tumors is tightly linked to the
carcinoma lesion, which is generally poor due to diagnostic delay. Large scale
strategies to eradicate H. pylori and
detect early lesions could reduce the mortality of this disease.