TITLE:
A New Dolabrane Dinorditerpene from Ceriops tagal
AUTHORS:
Xin Wu, Hongbo Liao, Hongyu Lu, Chaohua Zhang
KEYWORDS:
Ceriops tagal, Dolabrane, Tagalsine X, Cytotoxicity
JOURNAL NAME:
Open Access Library Journal,
Vol.3 No.8,
August
19,
2016
ABSTRACT: A new dolabrane dinorditerpene, tagalsine X(1), was isolated from the
leaves of Ceriops tagal, along with
five known analogues (2-6). Their structures were established on the basis of
spectroscopic data or comparison with the literatural data. Their cytotoxic
activities against four human carcinoma cell lines (CNE-2, HCT-116, HepG2and A549)
were also evaluated, which displayed that only compound 2 had significant
cytotoxicity against those cell lines with IC50 values of 13.57, 42.32, 11.21
and 15.23 μM, respectively.