TITLE:
Simple Insulin Dose Adjustment Using 3-3-1 Algorithm in Japanese Patients with Type 2 Diabetes: Start Kanazawa Study (Self-Titration Aggressive Algorithm with Glargine Trial)
AUTHORS:
Kenji D. Furukawa, Naoto Yamaaki, Aya Fujimoto, Kiminori Ohyama, Hiroaki Muramoto
KEYWORDS:
Glargine, Self-Titration, BOT, T2DM, Insulin, 3-3-1 Algorithm
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.6 No.3,
August
17,
2016
ABSTRACT: We implemented a 3-3-1 algorithm in order to provide safe and
simple self-titration in patients who newly initiated BOT as well as who were
already on BOT and evaluated its utility in clinical setting. A total of 46
patients, 21 patients in the newly-initiated group and 25 patients in the
existing BOT group performed dose adjustment using 3-3-1 algorithm. HbA1c was
significantly improved 4 weeks after the initiation from 8.5% ± 1.2% at
baseline to 7.3% ± 0.7% at the final evaluation (p0.01, vs. Baseline). The average daily insulin units
increased throughout the study period from 10.1 ± 6.7 at baseline to 14.6 ± 8.9
units at the final evaluation. Weight didn’t significantly change throughout
the study (p = 0.12). The incidents of hypoglycemia were 0.8/month during the
insulin dose self-adjustment period and 0.4/month during the follow-up period.The 3-3-1 algorithm using insulin glargine provided a safe
and simple dose adjustment and demonstrated its utility in patients who were
newly introduced to insulin treatment as well as who were already on BOT.