TITLE:
Evaluation of Some Inflammatory Biomarkers in Male Albino Wistar Rats Following Ingestion of Crude Oil and the Role of Bee Honey, Vitamins C and E
AUTHORS:
Sunday Otu Ita, Edet Okon Akpanyung, Akpoezoukumo Salima Robert, Esther Olusola Aluko, Faith Okon Eseabasi, Michael Uwem Sunday-Essien
KEYWORDS:
Crude Oil, Inflammation, Erythrocyte Sedimentation Rate, C-Reactive Protein, Antioxidants
JOURNAL NAME:
Modern Research in Inflammation,
Vol.5 No.3,
August
12,
2016
ABSTRACT: Evaluation of some
biomarkers of inflammation in male Albino Wistar rats following ingestion of
Nigerian Bonny Light Crude Oil (NBLCO) and the effect of antioxidant
supplementation was the focus of this study. Forty-eight adult male Albino
Wistar rats weighing 150 - 180 g were randomly divided 8 per group into: group
I (control) oral gavaged 3 ml/kg of normal saline; group II received 3 ml/kg of
NBLCO; groups III, IV and V received in addition to 3 ml/kg of NBLCO 1 ml/kg
vitamin C, vitamin E and 3 ml/kg of honey bee respectively; group VI received 3
ml/kg of honey. After 28 days of treatment, all animals were anaesthetized with
chloroform and blood collected by cardiac puncture for analysis. Results showed
that NBLCO administration significantly increased erythrocyte sedimentation
rate and C-reactive protein while supplementation with antioxidant
significantly reversed such effects (p