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Dansky, H.M., Shu, P., Donavan, M., Montagno, J., Nagle, D.L., Smutko, S., Roy, N., Whiteing, S., Barrios, J., McBride, T.J., Smith, J.D., Duyk, G., Breslow, J.L. and Moore, K.J. (2002) A Phenotype-Sensitizing Apoe-Deficient Genetic Background Reveals Novel Atherosclerosis Predisposition Loci in the Mouse. Genetics, 160, 1599-1608.

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• TITLE: Evaluation of Some Inflammatory Biomarkers in Male Albino Wistar Rats Following Ingestion of Crude Oil and the Role of Bee Honey, Vitamins C and E

  AUTHORS: Sunday Otu Ita, Edet Okon Akpanyung, Akpoezoukumo Salima Robert, Esther Olusola Aluko, Faith Okon Eseabasi, Michael Uwem Sunday-Essien

  KEYWORDS: Crude Oil, Inflammation, Erythrocyte Sedimentation Rate, C-Reactive Protein, Antioxidants

  JOURNAL NAME: Modern Research in Inflammation, Vol.5 No.3, August 12, 2016

  ABSTRACT: Evaluation of some biomarkers of inflammation in male Albino Wistar rats following ingestion of Nigerian Bonny Light Crude Oil (NBLCO) and the effect of antioxidant supplementation was the focus of this study. Forty-eight adult male Albino Wistar rats weighing 150 - 180 g were randomly divided 8 per group into: group I (control) oral gavaged 3 ml/kg of normal saline; group II received 3 ml/kg of NBLCO; groups III, IV and V received in addition to 3 ml/kg of NBLCO 1 ml/kg vitamin C, vitamin E and 3 ml/kg of honey bee respectively; group VI received 3 ml/kg of honey. After 28 days of treatment, all animals were anaesthetized with chloroform and blood collected by cardiac puncture for analysis. Results showed that NBLCO administration significantly increased erythrocyte sedimentation rate and C-reactive protein while supplementation with antioxidant significantly reversed such effects (p