TITLE:
The Impact of Ethnicity on the Incidence, Tumor Characteristics and Treatment of Ductal Carcinoma in Situ—An 11-Year Clinical Experience at a High Volume Teaching Hospital
AUTHORS:
Lauren S. Sparber, Vijayashree Murthy, Ronald S. Chamberlain
KEYWORDS:
Ductal Carcinoma in Situ, HER-2/Neu, Ethnicity, Race, Breast Neoplasms
JOURNAL NAME:
Surgical Science,
Vol.7 No.8,
August
12,
2016
ABSTRACT: Introduction: Screening mammography has led to a marked increase in
detection of in situ breast tumors in the United States. The University of
Southern California/Van Nuys Prognostic Index (USC/VNPI) predicts the
recurrence rates of ductal carcinoma in situ (DCIS); however variations in tumor
characteristics, USC/VNPI scores, receptor and human epithelial growth factor
receptor (HER)-2/neu status across different
ethnicities/races have not been well studied. This study aimed to evaluate the racial trends in incidence,
patient demographics, tumor characteristics and treatment variations for patients with DCIS at a high volume teaching
hospital. Methods: 395 women underwent
surgical intervention for DCIS between 2000 and 2011. Their race/ethnicity was
divided into five mutually exclusive categories and demographic and
clinicopathological data was collected.
Multivariate analysis was performed to evaluate variations in patient
and tumor factors with respect to age, size
and surgical management among different ethnicities and races. Results: 82.1%
of Caucasian women underwent simple mastectomy with sentinel lymph node biopsy (SLNB)
while lumpectomy with SLNB was highest in Hispanics (40%, p = 0.005). Overall, there was no significant difference in the
incidence of receptor or HER-2/neu positivity, multicentricity,
necrosis or grade of DCIS in the various racial groups, but there was a
significant racial difference in the USC/VNPI scores (p in DCIS
with respect to patient or tumor characteristics was observed, a racial
difference in USC/VNPI score was
identified among the Hispanic population. Additional studies are
required to validate the significance of these findings.