TITLE:
Comparison of the Analgesic Activity of Antiparkinsonian Aminoadamantane Derivatives Amantadine and Hemantane
AUTHORS:
Elena Ivanova, Inga Kapitsa, Elena Valdman, Tatyana Voronina
KEYWORDS:
NMDA Receptor Antagonists, Tail-Flick Test, Acetic Twitches, Formalin Test, Exudative Inflammation
JOURNAL NAME:
Advances in Parkinson's Disease,
Vol.5 No.3,
August
11,
2016
ABSTRACT: The efficacy of some aminoadamantane derivatives used as neurodegeneration treatments is due
to their ability to block NMDA receptors. But this mechanism of pharmacological action can also
produce analgesic activity. Analgesic properties of two aminoadamantanes, amantadine (20
mg/kg) and hemantane (20 mg/kg), which were uncompetitive NMDA receptor antagonists, were
assessed in rodent models of pain induced by different pain stimuli (tail-flick test, acetic twitches
test in mice and formalin test in rats). Additionally, the anti-inflammatory properties of hemantane
and amantadine were evaluated in mice with acetic peritonitis and in rats with hind paw
edema induced by formalin injection. The results of our study demonstrate that the analgesic activity
of the 1-aminoadamantane amantadine differs from the 2-aminoadamantane hemantane.
The analgesic activity of amantadine administered intraperitoneally was more pronounced in the
case of acute thermal pain in mice compared to hemantane, and only amantadine had a significant
analgesic effect on the acute early phase of formalin pain in rats induced by the effect of the algogen
on the primary sensory afferents. Hemantane was more effective than amantadine for relieving
pain produced by inflammation owing to its pronounced anti-inflammatory activity: only hemantane
decreased the amount of acetic twitches in mice that received drugs orally and was effective
in the tonic phase of formalin pain in rats.