TITLE:
Therapeutic Uses of Lycium barbarum Polysaccharides on Idiopathic Thrombocytopenic Purpura Mice via Inhibition of Oxidative Stress
AUTHORS:
Chengqiang Jin, Haixin Dong, Jianwei Zhou, Shuhua Lu, Xiaxia Yang, Zhenwen Qian, Yanxia Jia
KEYWORDS:
Lycium barbarum Polysaccharides, Idiopathic Thrombocytopenic Purpura, Total Antioxidant Status, Total Oxidant Status
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.4 No.8,
August
8,
2016
ABSTRACT: The aim of the present study was to investigate the
effect of Lycium barbarum polysaccharides (LBP) on the treatment of ITP mice and to explore its
mechanism. Forty idiopathic thrombocytopenic purpura (ITP) mice were divided
randomly into a model control group and LBP groups I, II, III and IV. ITP mice
in LBP groups I, II, III, and IV were administered LBP at four different doses
(50, 100, 200 and 400 mg·kg-1·d-1, respectively)
for 7 days by gavage. Blood samples were collected from the tail veins of the
mice after treatment. Platelet counts were determined, and the total antioxidant
status (TAS), total oxidant status (TOS) were measured with ELISA kits. The
platelet count was (30.28 ± 13.42) × 109/L in the model control group, and
the number of platelets in all LBP groups was higher than that in the model
control group. The platelet count increased, and it reached (67.09 ± 10.81) × 109/L in LBP
group I; the platelet counts in the other three groups increased significantly
compared to LBP group I, and they did not differ significantly. TAS
concentrations in the LBP groups were significantly increased compared to the model
control group, whereas TOS concentrations were significantly decreased. Taken
together, these results indicate that LBP is effective at increasing the number
of platelet (PLT), and LBP may treat ITP mice via suppressing oxidative stress.