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Omarini, D., Barzago, M.M., Bortolotti, A., Lucchini, G., Stellari, F., Enfrati, S. and Bonati, M. (1993) Placental transfer of theophylline in an in vitro closed perfusion system of human placenta isolated lobule. European Journal of Drug Metabolism and Pharmacokinetics, 18, 369-374.

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• TITLE: Medication induced fetal bladder rupture: a case report

  AUTHORS: Eldon Palmer, Milette Oliveros, Jason Fong, George Graham

  KEYWORDS: Bladder Rupture; Maternal Medication; Pharmacology; Fetal Urinary Retention; Fetal Ultrasound

  JOURNAL NAME: Open Journal of Obstetrics and Gynecology, Vol.1 No.2, June 30, 2011

  ABSTRACT: BACKGROUND: Intrauterine bladder rupture is a rare complication usually caused by structural bladder outlet obstruction. Some medications are known to cause urinary retention or diuresis in fetuses and preterm infants. CASE: A 31-year-old gravida 6, para 3023 at 29 weeks and 2 days’ gestation required intubation, mechanical ventilation, and medical management for severe chest pain and respiratory failure, eventually diagnosed as asthma and pneumonia. An obstetrical ultrasound on hospital day three revealed a markedly dilated fetal bladder. Repeat ultrasound the following day showed a decompressed fetal bladder and significant ascites. A cesarean delivery was performed for a nonreassuring fetal heart rate. Postnatal evaluation by voiding cystourethrogram and cystoscopy revealed bladder rupture without evidence of outlet obstruction. Given the absence of other plausible causes, the rupture was likely due to exposure to maternal medications. CONCLUSION: Transplacental exposure to maternal medications may cause fetal urinary retention and intrauterine bladder rupture. Fetal ultrasound surveillance during treatment with medications known to cause urinary retention may allow for early diagnosis and intervention.