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Wakeling, A.E., Guy, S.P., Woodburn, J.R., Ashton, S.E., Curry, B.J., Barker, A.J. and Gibson, K.H. (2002) ZD1839 (Iressa): An Orally Active Inhibitor of Epidermal Growth Factor Signaling with Potential for Cancer Therapy. Cancer Research, 62, 5749-5754.

has been cited by the following article:

• TITLE: Synthesis and Antitumor Activity of Novel Thienopyrimidine Derivatives Containing Thiosemicarbazide Moiety

  AUTHORS: Samir B. Salib, Omneya M. Khalil, Mona M. Kamel, Yara El-Dash

  KEYWORDS: Synthesis, Thieno[2, 3-d]Pyrimidine, Thiosemicarbazides, Anticancer Agents

  JOURNAL NAME: Open Access Library Journal, Vol.3 No.7, July 26, 2016

  ABSTRACT: The present study focused on synthesizing a series of novel derivatives of 4-aryl-1-[2-(3-benzyl-4-oxo(3H)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-ylsulphanyl) acetyl] thiosemicarbazide 5a-d and evaluating their antitumor activity. The structure of the synthesized compounds has been elucidated on the basis of elemental analyses and spectroscopic methods (IR, 1H-NMR, 13C-NMR and MS). The in vitro cytotoxic activity of the synthesized derivatives was evaluated against two human cell lines: prostate cancer (PC-3) and colon cancer (HCT-116).