TITLE:
Correlation between Inflammatory Markers and Lipid Parameters in a Tunisian Coronary Artery Disease Group
AUTHORS:
Rihab Sendesni, Dhaker Lahidheb, Manel Ayoub, Nedra Grira, Dhekra Lafi, Nejla Stambouli, Mabrouka El Oudi, Ezzedine Ghazouani, Habib Haouala, Zied Aouni, Chakib Mazigh
KEYWORDS:
Inflammation, Lipids, Acute Coronary Syndrome
JOURNAL NAME:
Open Access Library Journal,
Vol.3 No.5,
May
18,
2016
ABSTRACT: Aims: To evaluate the relationship between inflammatory biomarkers and lipid
parameters in a Tunisian coronary artery disease group. Material and Methods: In
the study, we have included 122 subjects with acute coronary syndrome (ACS) confirmed
by coronary angiography, selected among patients admitted to the cardiology department
and 162 subjects free of any cardiovascular disease, recruited from medical and
paramedical volunteers. Lipid parameters, high sensitivity CRP (hsCRP) and proinflammatory
cytokines (IL6, IL8 and TNFα) were determined
for all patients and controls. Results: A highly significant difference (P ﹣3) was noted between the mean of the hsCRP in coronary
patients (14.65 ± 9.81 mg/L) compared to controls (1.63 ± 1.75 mg/L). We
note also a significant difference between the means of IL6 in the diseased population
(11.56 ± 8.23 pg/mL) compared to controls (2.5 ± 0.84 pg/mL) with a value
of P ﹣3. The hsCRP values are inversely correlated with the
HDLc values. No association was found between IL 8 and the various lipid parameters.
Patients having high IL6 values had higher levels of CT and CT/HDLc ratio. This
correlation is statistically significant. Regarding TNFα, there is a positive and significant correlation with CT and LDLc.
Conclusion: Significant correlation was found between inflammatory markers and lipids
profile. This may explain the role of inflammation in the development of cardiovascular
disease.