TITLE:
Hypercalcemia Due to Parathyroid Hormone-Related Protein Induced by Primary Endometrial Clear Cell Adenocarcinoma: Case Report
AUTHORS:
Kyousuke Takeuchi, Akari Shirakuni, Ai Yoshida, Akiko Takeda, Makoto Sugimoto
KEYWORDS:
Humoral Hypercalcemia of Malignancy, Endometrial Cancer, Clear Cell Adenocarcinoma, Parathyroid Hormone-Related Protein
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.6 No.9,
August
3,
2016
ABSTRACT: Humoral Hypercalcemia of Malignancy (HHM) has been reported in
association with a number of malignancies. In gynecologic malignancies, ovarian
Clear Cell Carcinoma (CCC) is one of the most commonhistologic subtypes,
whereas HHM caused by endometrial CCC is very rare. We report a case of
endometrial CCC with HHM, with a low serum intact PTH level, elevated serum
PTH-related Peptide (PTH-rP), and immunohistochemically demonstrated PTH-rP in
the neoplasm.