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Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M.I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., Lamuela-Raventos, R.M., Serra-Majem, L., Pintó, X., Basora, J., Mu?oz, M.A., Sorlí, J.V., Martínez, J.A. and Martínez-González, M.A. (2013) Primary Prevention of Cardiovascular Disease with a Mediterranean Diet. New England Journal of Medicine, 368, 1279-1290.
http://dx.doi.org/10.1056/NEJMoa1200303

has been cited by the following article:

• TITLE: Differential Anti-Inflammatory Effects of Three Purified Omega Unsaturated Fatty Acids on Collagen-Induced Arthritis in Mouse

  AUTHORS: Pamela Izaret Pérez-Martínez, Víctor Gabriel Hernández, Oscar Rodríguez-Espinosa, Patricia Arce-Paredes, Oscar Rojas-Espinosa

  KEYWORDS: Collagen, CIA, DBA-1 Mice, Omega-UFAs, Dexamethasone, Anti-Inflammatory

  JOURNAL NAME: Modern Research in Inflammation, Vol.5 No.3, August 2, 2016

  ABSTRACT: Background: The Mediterranean Diet (MD) has been linked to a reduced risk of developing degenerative diseases, including atherosclerosis, heart stroke, diabetes, arthritis and cancer. However, only a few scientific investigations have attempted to validate this impression. The ingredients of the MD include significant amounts of omega (ω3,ω6, andω9) unsaturated fatty acids (UFAs). A few studies of these UFAs in the prevention or treatment of arthritis have yielded controversial results, but a general belief regarding their beneficial effects has prevailed. Objective: To investigate the effects of three relevant UFAs, namely Docosahexaenoic Acid (DHA), Arachidonic Acid (AA), and Oleic Acid (OA) (ω3,ω6, andω9, respectively), in the development of arthritis using a murine model of Collagen-Induced Arthritis (CIA). Methods: DBA-1 mice were immunized with chicken collagen type II (CII) and were subsequently treated withω-UFAs for 53 days. Dexamethasone (DEXA) was used as a positive anti-inflammatory agent. The effect of the treatments was evaluated through several parameters: inflammation indices, antibody levels, cell prolifera- tion, and histopathological findings. Results and Conclusion: The anti-inflammatory effect of the tested substances was inversely correlated with the histopathological findings: a greater anti- inflammatory effect was associated with less articular damage. Oleic acid (ω9) was the most efficient anti-inflammatory UFA, followed by DHA and then AA. DEXA completely inhibited the development of arthritis, whereas the untreated CII-immunized mice developed the most severe articular damage. DBA-1 mice with CII-induced arthritis constitute an adequate model for the study of arthritis and its treatment.