TITLE:
Evaluation of Antalgic Activity and Trace Elements Analysis of Trema guineensis Extracts in Acetic Acid Induced in Rats
AUTHORS:
Yeboue Koffi F. Kouakou, Houphouet F. Yapi, Gnogbo Alexis Bahi, Goueh Gnahoue, Allico J. Djaman
KEYWORDS:
Trema guineensis, Oligosol, Trace Elements, Acetic Acid, Pain
JOURNAL NAME:
Open Access Library Journal,
Vol.3 No.5,
May
30,
2016
ABSTRACT: We evaluated centrally acting analgesic potential using tail immersion test and peripheral pharmacological actions using acetic acid induced writhing test in rats. The crude extracts of Trema guineensis leave plant were found to have significant analgesic activity at the intraperitoneal dose of 200 mg/kg body weight in two models. In the tail immersion test Trema guineensis increased significantly (P and 45 min. The aim of this study is also to determine the trace elements content in suffering rats of pain induced by acetic acid, using Atomic Spectrophotometer Absorption. Our results showed that trace element concentrations in Trema guineensis ethanolic extract in rats were as follows: Zn (6.92 ± 0.39 mg/L), Fe (37.95 ± 0.04 μmol/L), Cu (8.16 ± 0.12 mg/L) and Mn (0.56 ± 0.12 mg/L). We found following values with aqueous extract compared to NaCl as control: Zn (5.03 ± 0.47 mg/L), Fe (31.08 ± 0.07 μmol/L), Cu (6.69 ± 0.53 mg/L) and Mn (0.51 ± 0.07 mg/L). The intake of trace elements by TGE would lessen the pain generated in acetic acid in rats; this action is much more remarkable with the ethanol extract.