TITLE:
Correlation between C-Peptide Level and Chronic Microvascular Complications in Type 2 Diabetes Mellitus Sudanese Patients
AUTHORS:
Khalid Mohamed Adam, Shiraz Tajelsir, Deya Aldeen Aowad
KEYWORDS:
C-Peptide, Diabetic Complications, Nephropathy, Peripheral Neuropathy, Retinopathy
JOURNAL NAME:
Open Access Library Journal,
Vol.3 No.5,
May
24,
2016
ABSTRACT: Background: C-peptide is a by-product of insulin biosynthesis released in
the circulation in amount equimolar with that of insulin; therefore C-peptide
has been used as an index of insulin secretion and its potential role as a
predictor of pancreatic and colorectal cancer and kidney disease have been
questioned. The relation between C-peptide and diabetic complications attracted
the attention of many investigators but not well established yet. The aim of
the present study was to explore the relationship between the level of
C-peptide and the diabetic microvascular complications in Sudanese patients.
Patients and Methods: One hundred and eighty-one type 2 diabetic patients, 61%
males and 39% females, aged more than 30 years were recruited from different
Khartoum hospitals and studied cross-sectionally. Levels of blood C-peptide and
HbA1C were measured with commercially available ELISA kit, and the diabetic
complications were determined subjectively by experienced physicians. Results:
Patients with no complications showed the highest prevalence 33.7% followed by
peripheral neuropathy 33.1%, retinopathy 21.2% and finally nephropathy 11%. Both
no-complications (9.05 ± 3.288) and retinopathy (9.10 ± 3.34) groups showed
similar level of C-peptide, P value = 0.939. While nephropathy group (5.50 ± 3.73)
and peripheral neuropathy (6.60 ± 3.02) showed significantly low levels as compared
to that of no complication, P value = 0.000. On the other hand, level of HbA1C
showed difference between retinopathy and nephropathy when compared to no
complication group but not the peripheral neuropathy. Conclusion: The results
of the present study suggest that the most prevalent diabetic complication in
Sudanese patients is peripheral neuropathy, and the association between
C-peptide and diabetic complications is more prominent with nephropathy and peripheral
neuropathy rather than retinopathy.