TITLE:
“Natural Site-Directed Mutagenesis” Might Exist in Eukaryotic Cells
AUTHORS:
Gao-De Li
KEYWORDS:
Natural Site-Directed Mutagenesis, Genetic Alteration, Mutation, CAGFs, DNA to DNA Transcription, Drug Resistance, Evolution of Eukaryotes, Antibody Diversity, Somatic Hypermutation
JOURNAL NAME:
Open Access Library Journal,
Vol.3 No.4,
April
18,
2016
ABSTRACT: Site-directed mutagenesis refers to a man-made molecular biology method that
is used to make genetic alterations in the DNA sequence of a gene of interest. But
based on our recently published experimental findings, we propose that “natural
site-directed mutagenesis” might exist in eukaryotic cells, which is triggered by
harmful agents and co-directed by special transcription hotspots and mutation-contained
intranuclear primers.