TITLE:
Herpes Simplex Virus 1, Cytomegalovirus and Epstein Barr Virus Detection in Patients with Chronic and Aggressive Periodontitis
AUTHORS:
Harold H. Hernández, Andreína S. Fernandes, Laura A. Escalona, María Correnti
KEYWORDS:
Periodontitis, Gingival Crevicular Fluid, Cytomegalovirus, Herpes Simplex Virus, Epstein Barr Virus
JOURNAL NAME:
Open Access Library Journal,
Vol.3 No.3,
March
25,
2016
ABSTRACT: Recent investigations suggest that the viruses of the family
Herpesviridae are associated with periodontal disease, demonstrating a possible
association with the presence of Human Cytomegalovirus (HCMV), Herpes Simplex
Virus 1 (HSV-1) and Epstein Barr Virus (EBV) in periodontal tissues. Aim: To
analyze the association between the presence of HSV-1, HCMV and EBV in patients
with chronic or aggressive periodontitis. Methods: Crevicular fluid samples
were collected from 11 patients with aggressive periodontitis (AgP), 11 with
chronic periodontitis (CP) and 11 healthy control subjects (CG). The following
clinical parameters were measured: plaque index (PI), bleeding on probing
(BOP), probing depths (PD) and clinical attachment loss (CAL). Viral detection
was performed by PCR for HSV-1, HCMV and EBV. Results: HCMV was detected in
27.3% of AgP patients but not detected in CP and healthy subjects; HSV-1 in
27.3% of AgP and CP group and in 9.1% of CG. EBV-1 was detected in 18.2% of CP
patients and 9.1% of the CG. HCMV and HSV-1 coinfection was detected in 18.8%
of AgP patients and 9.09% of viral coinfection between HSV-1 and VEB, within
the CP group. The AgP group exhibited the higher values for all clinical parameters
evaluated, respect to the CP and control group. Conclusion: The presence of
HCMV may be related to periodontal disease, specifically in cases of AgP, and
it may play a synergistic role with other infectious agents from the oral
cavity associated with the development of periodontitis.