TITLE:
Immunomodulation of Human Carcinogenesis by the Blood Serum Antibodies against Benzo[a]pyrene, Estradiol and Progesterone
AUTHORS:
Andrey N. Glushkov, Elena G. Polenok, Valentin A. Ustinov
KEYWORDS:
Benzo[a]pyrene, Estradiol, Progesterone, Antibody, Anti-Idiotypic Antibody, Immunoglobulins A, Polycyclic Aromatic Hydrocarbons, Immunology, Lung Cancer, Breast Cancer, Cancer Risks
JOURNAL NAME:
Open Journal of Immunology,
Vol.6 No.3,
July
27,
2016
ABSTRACT: It was supposed that lung and breast cancer risks significantly increased when the levels of serum
immunoglobulins A antibodies against benzo[a]pyrene and estradiol increased together, but did
not separately. However, the cancer risks dramatically decreased when the levels of immunoglobulins
A against progesterone elevated separately or together with immunoglobulins A against
benzo[a]pyrene and estradiol. So, immunoglobulins A against benzo[a]pyrene and immunoglobulins
A against estradiol acted as co-initiator and co-promoter in developing cancer scenario, but
immunoglobulins A against progesterone acted along or conjointly with immunoglobulins A
against benzo[a]pyrene and estradiol as strongly inhibitor in human carcinogenesis. Also it was
suggested the precise mechanism of carcinogenesis modulation using anti-idiotypic antibodies
against estradiol and progesterone through their membrane steroid receptors.