Article citationsMore>>

Glushkov, A.N., Polenok, E.G., Verzhbitskaja, N.E., Titov, V.A., Vafin, I.A. and Ragozina, S.E. (2014) Antibodies to Chemical Carcinogen and Steroid Hormones in Lung Cancer Patients. Russian Journal of Immunology, 2, 219-227. (In Russian)

has been cited by the following article:

• TITLE: Immunomodulation of Human Carcinogenesis by the Blood Serum Antibodies against Benzo[a]pyrene, Estradiol and Progesterone

  AUTHORS: Andrey N. Glushkov, Elena G. Polenok, Valentin A. Ustinov

  KEYWORDS: Benzo[a]pyrene, Estradiol, Progesterone, Antibody, Anti-Idiotypic Antibody, Immunoglobulins A, Polycyclic Aromatic Hydrocarbons, Immunology, Lung Cancer, Breast Cancer, Cancer Risks

  JOURNAL NAME: Open Journal of Immunology, Vol.6 No.3, July 27, 2016

  ABSTRACT: It was supposed that lung and breast cancer risks significantly increased when the levels of serum immunoglobulins A antibodies against benzo[a]pyrene and estradiol increased together, but did not separately. However, the cancer risks dramatically decreased when the levels of immunoglobulins A against progesterone elevated separately or together with immunoglobulins A against benzo[a]pyrene and estradiol. So, immunoglobulins A against benzo[a]pyrene and immunoglobulins A against estradiol acted as co-initiator and co-promoter in developing cancer scenario, but immunoglobulins A against progesterone acted along or conjointly with immunoglobulins A against benzo[a]pyrene and estradiol as strongly inhibitor in human carcinogenesis. Also it was suggested the precise mechanism of carcinogenesis modulation using anti-idiotypic antibodies against estradiol and progesterone through their membrane steroid receptors.