TITLE:
Evaluation of Targeted Therapy for Locally Advanced or Metastatic Renal Cell Carcinoma in Tunisia
AUTHORS:
Khaled Ben Ahmed, Amira Daldoul, Ghassen Tlili, Laila Ben Fatma, Olfa Gharbi, Mahdi Afrit, Jihene Fkih, Hammouda Boussen, Mounir Frikha, Faouzi Mosbah, Slim Ben Ahmed
KEYWORDS:
Renal Cell Carcinoma, Metastasis, Molecular Targeted Therapy, Sunitinib, Drug Tolerance
JOURNAL NAME:
Open Journal of Gastroenterology,
Vol.6 No.7,
July
27,
2016
ABSTRACT: Introduction: Renal cell carcinoma (RCC) is known to be chemo resistant but with the introduction of targeted therapies; there has been a “revolution” in its treatment strategies. The only targeted therapy available in Tunisia for the treatment of metastatic and/or locally advanced RCC is sunitinib. Objective of the Study: To evaluate therapeutic results and tolerance of sunitinib in metastatic and/or locally advanced RCC. Subjects and Methods: This was a retrospective study covering a period of six years (from January 2008 to January 2014) conducted in 5 medical oncology departments in Tunisia. The population of the study consisted of 29 patients treated with sunitinib for metastatic and/or locally advanced RCC. Results: The mean age of patients was 51 years. Three patients had tumor recurrence and 26 patients had a metastatic RCC. The prognosis was good for 5 patients, intermediate for 19 patients and poor for 5 patients. The median duration of treatment was 5 months. Because of side effects, treatment was discontinued in 12.5% of cases and the dose was reduced in 10.3% of cases. Side effects consisted of asthenia (95.8%), stomatitis (70.8%), anemia (50%), hand-foot syndrome (55.8%) in addition to nausea and vomiting (54.2%). Objective response was observed in 37.5% of patients after 3 months of treatment and in 50% after 6 months. The median progression-free survival was 14 months (95% CI, 7.9 to 20.6). The median overall survival was 22 months (95% CI, 15.6 to 28.7). Conclusion: The prognosis of RCC in Tunisian patients has clearly improved with the introduction of sunitinib, but other therapies with a proven efficacy as a first and second line therapy should be considered.