TITLE:
Antiestrogenic Compounds and Breast Cancer
AUTHORS:
Muhammad Asim, Noman Ali, Raheel Asghar, Awais Amin, Muhammad Saif Ur Rahman
KEYWORDS:
Breast Cancer, Anti-Estrogen Compounds, Bcl-2, GRP78, Caspase 8
JOURNAL NAME:
Open Access Library Journal,
Vol.3 No.3,
March
18,
2016
ABSTRACT: Breast cancer is the main threat around the world. Estrogen and estrogen
receptors (ER) assume a noteworthy part in breast disease movement and
advancement. Breast cancer is the most pervasive disease in women, every year
more than 200,000 new cases analyzed. Estrogen receptors are expressed in 70%
of all the breast cancer cases, so it is an important target for the treatment
of breast cancer. Anti-estrogen compounds are of significant importance since
it can be used as a therapy for breast cancer. In this review we have
summarized the most important anti-estrogen compounds being used for the
treatment of the breast cancer and their related molecular pathways with the
hope that this will enhance our understanding to these compounds.