TITLE:
Analyzing Nootropic Effect of Phyllanthus reticulatus Poir. on Cognitive Functions, Brain Antioxidant Enzymes and Acetylcholinesterase Activity against Aluminium-Induced Alzheimer’s Model in Rats: Applicable for Controlling the Risk Factors of Alzheimer’s Disease
AUTHORS:
Md. Sahab Uddin, Abdullah Al Mamun, Mohammed Ashraful Iqbal, Ariful Islam, Md. Farhad Hossain, Sayema Khanum, Mamunur Rashid
KEYWORDS:
Nootropic, Phyllanthus reticulatus, Cognitive Functions, Brain Antioxidant Enzymes, Acetylcholinesterase Activity, Alzheimer’s Disease
JOURNAL NAME:
Advances in Alzheimer's Disease,
Vol.5 No.3,
July
21,
2016
ABSTRACT: Oxidative stress is intensely linked with neurodegenerative disorders, especially Alzheimer’s disease
(AD). Searching for medicinal plant with the nootropic activity for controling the development
and progression of AD has received extensive consideration. The plant Phyllanthus reticulatus
(PR) Poir. is known in Bengali as Panjuli belongs to family Euphorbiaceae. Previous studies
have shown the antioxidant, analgesic, anti-inflammatory, etc. activities of this plant. Therefore,
the objective of this study was to examine the nootropic effect of ethanolic extracts of Phyllanthus
reticulatus (EEPR) on cognitive functions, brain antioxidatant enzymes and acetylcholinesterase
activity in aluminium-induced rats of cognitive impairment and oxidative stress. The effects of
EEPR fruit (i.e., 100 and 200 mg/kg b.w.) were examined for 30 days and its nootropic effect was
determined in aluminium treated Swiss albino male rats by behavioral studies such as Passive
Avoidance (PA) test, Rewarded Alternation (RA) test and biochemical studies such as superoxide dismutase (SOD), catalase (CAT), contents of thiobarbituric acid reactive substances (TBARS) and
acetylcholinesterase (AChE) activity in rats brain tissue homogenates. In PA test, administration of
EEPR fruit (i.e., 100 and 200 mg/kg, b.w.) significantly (P