TITLE:
Innovation of Neuropsychopharmacological Experimental Methods to Investigate Attention in Human Participants and Its Validation by Randomized Double Blind Placebo Controlled Clinical Trial
AUTHORS:
Md. Sahab Uddin, Abdullah Al Mamun, Md. Asaduzzaman
KEYWORDS:
Neuropsychopharmacology, Numeral Finding Test, Typo Revealing Test, Attention, Clinical Trial
JOURNAL NAME:
Journal of Behavioral and Brain Science,
Vol.6 No.7,
July
19,
2016
ABSTRACT: In terms of
advancement of life to meet the challenges new method for neuropsychopharmacological
research are continually developing to ensure superior safety, accuracy,
efficacy, precision etc. In this experiment, we suggested and validated two
neuropsychopharmacological testing methods, these are Numeral Finding (NF) and
Typo Revealing (TR) tests for the determination of attention in healthy aged human
participants. The objective of this experiment was to generate more effective
testing methods for the assessment of attention in human. The rationality of
the aforementioned methods was checked by a randomized double blind placebo
controlled clinical trial for the period of 21 days among healthy aged human
participants. The experiment was conducted at Gazipur Sadar, Gazipur-1703,
Dhaka, Bangladesh between the period of December 2015 and March 2016. The experiment
center was the Department of Pharmacy, Southeast University, Dhaka-1213,
Bangladesh. In this experiment, 60 healthy male participants between the age
ranges of 40 to 50 years old were selected and randomly divided by simple randomization
process into 3 groups with 20 participants in each. Ginkgo biloba standardized extract’s capsule (Giloba? and Kobi?) was used as a standard and as a placebo control psyllium
seed husk (i.e., seed of the Plantago ovata) was used after filling
in the hard gelatin capsule shell (size 0). Group 1 was treated with Giloba? in which each capsule contained 120 mg Ginkgo biloba standardized extract (GBG) and group 2 was treated
with Kobi? in which each capsule contained 60 mg Ginkgo biloba standardized extract
(GBK). The treatment procedure for group 3 was psyllium seed husk’s capsule
that served as placebo control (PC). Throughout the experiment each capsule was
administered 3 times daily. Treatment with Ginkgo
biloba standardized extracts for successive days markedly increased the
attention of the participants with respect to PC group. In the NF test,
administration of GBG and GBK extracts significantly (P P P th and 21st day as compared to
that of PC group. For TR test treatment with GBG and GBK extracts markedly (P P P th and 21st day with respect to PC group. The existing experiment proved that NF and TR
tests undoubtedly revealed the attention enhancing activity of the Ginkgo biloba standardized extracts in
healthy aged human participants. Consequently, the recommended newly emerging
methods can be used for the assessment of attention in human and will create a
miracle in the domain of neuroscience.