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Fiorucci, S., Antonelli, E., Santucci, L., Morelli, O., Miglietti, M., Federici, B., Mannucci, R., Del Soldato, P. and Morelli, A. (1999) Gastrointestinal Safety of Nitric Oxide-Derived Aspirin Is Related to Inhibition of ICE-Like Cysteine Proteases in Rats. Gastroenterology, 116, 1089-1106.
http://dx.doi.org/10.1016/S0016-5085(99)70012-0

has been cited by the following article:

• TITLE: Prevalence of Nsaids (Non Steroidal Inflammatory Drugs) as a Chemopreventive Agent in Different Types of Cancer: Retrospective Detail Studies

  AUTHORS: Maria Ayub, Amna Islam

  KEYWORDS: NSAIDs, Chemopreventiveuse, Chemopreventive Mechanism, Risk and Benefits of Aspirin, Other NSAIDs as Chemopreventive Agents

  JOURNAL NAME: Open Access Library Journal, Vol.2 No.8, August 31, 2015

  ABSTRACT: NSAIDs are the most widely used drugs globaly and are very famous for their analgesic, anti-in-flammatory and antipyretic actions. The use of NSAIDs in a variety of cancerous conditions is also approved now because of its versatile pharmacologic actions. In this research based study the use of NSAIDs as a chemointerceptive agent in a variety of cancers has been discussed. We aimed to know about the chemopreventive effects of NSAIDs that are a very diverse group of drugs having a lot of pharmacological actions. Now they are advised to prevent from various types of cancers by its different mechanisms and processes like inhibition of angiogenesis, COX-2 and it potentiates the process of apoptosis which is also a very favourable point for NSAIDs to work as a chemointerceptive agent. Heeding to the results aspirin could intercept from cancer (37%) and other NSAIDs used as acheminterceptive agents (28%). All of the NSAIDs have less side effects as compared to the drugs that are used during chemotherapy. The inhibition of COX-1 enzyme by NSAIDs is (15%) and that of COX-2 (85%). Studies suggested that the most frequent cancer in males is 14.5% of colorectal cancer and 10% prostate cancer while in female the most common cancers are 27% of breast cancer and 15% of colorectal cancer. 30% of ovarian cancer is also very common in many females of elder age groups. It was concluded that NSAIDs are a diverse group of drugs and advised to manipulate as a chemointerceptive agents in a variety of cancers. Besides these studies there are many limitations heeding to the chronic usage of NSAIDs, which should also be considered. The use of NSAIDs as a chemointerceptive agent requires more further experimental studies and needs clinical trials.