TITLE:
Prevalence of Nsaids (Non Steroidal Inflammatory Drugs) as a Chemopreventive Agent in Different Types of Cancer: Retrospective Detail Studies
AUTHORS:
Maria Ayub, Amna Islam
KEYWORDS:
NSAIDs, Chemopreventiveuse, Chemopreventive Mechanism, Risk and Benefits of Aspirin, Other NSAIDs as Chemopreventive Agents
JOURNAL NAME:
Open Access Library Journal,
Vol.2 No.8,
August
31,
2015
ABSTRACT: NSAIDs are the most widely used drugs globaly and are very famous for
their analgesic, anti-in-flammatory and antipyretic actions. The use of NSAIDs
in a variety of cancerous conditions is also approved now because of its
versatile pharmacologic actions. In this research based study the use of NSAIDs
as a chemointerceptive agent in a variety of cancers has been discussed. We
aimed to know about the chemopreventive effects of NSAIDs that are a very
diverse group of drugs having a lot of pharmacological actions. Now they are
advised to prevent from various types of cancers by its different mechanisms
and processes like inhibition of angiogenesis, COX-2 and it potentiates the
process of apoptosis which is also a very favourable point for NSAIDs to work
as a chemointerceptive agent. Heeding to the results aspirin could intercept
from cancer (37%) and other NSAIDs used as acheminterceptive agents (28%). All of
the NSAIDs have less side effects as compared to the drugs that are used during
chemotherapy. The inhibition of COX-1 enzyme by NSAIDs is (15%) and that of COX-2 (85%). Studies suggested that the most
frequent cancer in males is 14.5% of colorectal cancer and 10% prostate
cancer while in female the most common cancers are 27% of breast cancer and 15%
of colorectal cancer. 30% of ovarian cancer is also very common in many females
of elder age groups. It was concluded that NSAIDs are a diverse group of drugs
and advised to manipulate as a chemointerceptive agents in a variety of
cancers. Besides these studies there are many limitations heeding to the
chronic usage of NSAIDs, which should also be considered. The use of NSAIDs as
a chemointerceptive agent requires more further experimental studies and needs
clinical trials.