TITLE:
Clinical Course of Lung Cancer Patients with Subcutaneously Implanted Central Venous Access Device Ports from the Time of Receiving Chemotherapy to the Endpoint of Cancer
AUTHORS:
Tomonori Hirashima, Teppei Tsumori, Kenichi Sakai, Makoto Fujishima, Yukie Yamakawa, Noriko Ryouta, Masumi Sandoh, Takayuki Shiroyama, Motohiro Tamiya, Naoko Morishita, Hidekazu Suzuki, Norio Okamoto, Sho Goya, Hironori Shigeoka
KEYWORDS:
Clinical Course, At-Home Death Rate, Implanted Central Venous Access Device Port, Lung Cancer, Seamless Oncological Care
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.7 No.7,
July
13,
2016
ABSTRACT: Background: As the prognosis of lung cancer (LC)
patients improves, subcutaneously implanted central venous access device ports
(CV-ports) have frequently been used for continuing chemotherapy (CC) or
palliative care (PC). In this study, we examined the clinical course of LC
patients with subcutaneously implanted CV-ports from the time of receiving
chemotherapy to the endpoint of cancer. Materials and Methods: We
retrospectively reviewed the clinical data and treatment history of LC patients
with subcutaneously implanted CV-ports between June 2008 and November 2013
using clinical records and a pharmacy database. Results: Of the 132 LC patients
with subcutaneously implanted CV-ports, 79 (59.8%) had CV-ports for CC (the CC
group) and 53 (40.2%) had CV-ports for PC (the PC group). After CV-port
implantation, LC patients in the CC group received a median of two regimens
with a median of 6 cycles. The median survival time of patients in the CC and
PC groups was 457 and 44 days, respectively. In the CC group, the median
survival time of small cell and non-small cell LC patients was 342 (95%
confidence interval, 235 - 627) and 563 (95% confidence interval, 368 - 728)
days, respectively. Nine patients (6.8%) had their CV-ports removed due to
complications. Forty (30.3%) of the 132 enrolled patients were referred for
at-home PC. The at-home death rate observed among these 40 patients was 30.0% (N = 12). Conclusion: CV-ports may
contribute to seamless oncological care.