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Mitsudomi, T., Morita, S., Yatabe, Y., et al. (2012) Updated Overall Survival Results of WJTOG 3405, a Randomized Phase III Trial Comparing Gefitinib (G) with Cisplatin Plus Docetaxel (CD) as the First-Line Treatment for Patients with Non-Small Cell Lung Cancer Harboring Mutations of the Epidermal Growth Factor Receptor (EGFR). Journal of Clinical Oncology, 30, 7521.

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• TITLE: Clinical Course of Lung Cancer Patients with Subcutaneously Implanted Central Venous Access Device Ports from the Time of Receiving Chemotherapy to the Endpoint of Cancer

  AUTHORS: Tomonori Hirashima, Teppei Tsumori, Kenichi Sakai, Makoto Fujishima, Yukie Yamakawa, Noriko Ryouta, Masumi Sandoh, Takayuki Shiroyama, Motohiro Tamiya, Naoko Morishita, Hidekazu Suzuki, Norio Okamoto, Sho Goya, Hironori Shigeoka

  KEYWORDS: Clinical Course, At-Home Death Rate, Implanted Central Venous Access Device Port, Lung Cancer, Seamless Oncological Care

  JOURNAL NAME: Journal of Cancer Therapy, Vol.7 No.7, July 13, 2016

  ABSTRACT: Background: As the prognosis of lung cancer (LC) patients improves, subcutaneously implanted central venous access device ports (CV-ports) have frequently been used for continuing chemotherapy (CC) or palliative care (PC). In this study, we examined the clinical course of LC patients with subcutaneously implanted CV-ports from the time of receiving chemotherapy to the endpoint of cancer. Materials and Methods: We retrospectively reviewed the clinical data and treatment history of LC patients with subcutaneously implanted CV-ports between June 2008 and November 2013 using clinical records and a pharmacy database. Results: Of the 132 LC patients with subcutaneously implanted CV-ports, 79 (59.8%) had CV-ports for CC (the CC group) and 53 (40.2%) had CV-ports for PC (the PC group). After CV-port implantation, LC patients in the CC group received a median of two regimens with a median of 6 cycles. The median survival time of patients in the CC and PC groups was 457 and 44 days, respectively. In the CC group, the median survival time of small cell and non-small cell LC patients was 342 (95% confidence interval, 235 - 627) and 563 (95% confidence interval, 368 - 728) days, respectively. Nine patients (6.8%) had their CV-ports removed due to complications. Forty (30.3%) of the 132 enrolled patients were referred for at-home PC. The at-home death rate observed among these 40 patients was 30.0% (N = 12). Conclusion: CV-ports may contribute to seamless oncological care.