TITLE:
Clinical Research on the Method of Huafu Zaisheng in Treating Diabetic Foot with Tendons Necrotic
AUTHORS:
Chaojun Zhu, Jing Ma, Xianzhou Liu, Xuya Lu, Qiang Xu, Zhaohui Zhang
KEYWORDS:
Huafu Zaisheng, Diabetic Foot, Bromelain, Shengji Corium Elephatis Mastic, Tendons
JOURNAL NAME:
Open Access Library Journal,
Vol.3 No.2,
February
5,
2016
ABSTRACT: Objective: To observe the effect of liquefying the necrotic tendons of diabetic
foot and promotion of wound healing using the treatment of Huafu Zaisheng. Methods:
98 patients suffering from diabetic foot were randomly divided into Huafu Zaisheng
group (35 cases), Huafu group (32 cases), Zaisheng group (31 cases), and then had
eroded debridement timely for its wounds. Since then, different methods and drugs
applied to deal with the wound, observe the liquefaction time and detachment time
of the degeneration and necrosis tendon, and observe the wound healing. Collection
and preservation of wound secretion, determine the pH value of wound secretion,
determination content of the NO and TGF-β1
in wound secretion. Wound tissue containing fascia and tendons was extracted by
surgical methods, before treatment and 6, 12 weeks after treatment. All tissue samples
were prepared according to Hematoxylin-eosin staining techniques, after which their
appearance was evaluated for pathological changes using an optical microscope. Immunohistochemistry
staining was used to detect the expressions of CD34 and CK19. Results: By comparison
of the efficacy of the three groups, the curative effect of the HFZS group is superior
to HF and ZS group. The necrotic tendons of Huafu Zaisheng group were liquefied
clearer than the other two groups. Three groups of secretions pH value were the trend of first decreased, then
increased, weakly basic first, and then weak acid, and then close to neutral. Compared
to ZS group and HF group, the difference was statistically significant (P β1 content of HFZS group increased significantly, and the difference
was statistically significant (P β1)
and microenvironment for wound healing.