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Smits, M.L.J., Elschot, M., van den Bosch, M.A.A.J., van de Maat, G.H., van het Schip, A.D., Zonnenberg, B.A., Seevinck, P.R., Verkooijen, H.M., Bakker, C.J., de Jong, H.W.A.M., Lam, M.G.E.H. and Nijsen, J.F.W. (2013) In Vivo Dosimetry Based on SPECT and MR Imaging of 166Ho-Microspheres for Treatment of Liver Malignancies. The Journal of Nuclear Medicine, 54, 2093-2100.
http://dx.doi.org/10.2967/jnumed.113.119768

has been cited by the following article:

• TITLE: SIRT and Its Unresolved Problems—Is Imaging the Solution? A Review

  AUTHORS: Franziska Schulz, Michael Friebe

  KEYWORDS: Selective Internal Radiation Therapy (SIRT), Radioembolization, Yttrium 90, Holmium 166, Liver Tumors

  JOURNAL NAME: Journal of Cancer Therapy, Vol.7 No.7, July 12, 2016

  ABSTRACT: Selective Internal Radiation Therapy (SIRT) is used as a treatment option for unresectable liver tumors. In SIRT, microspheres, which have a radioactive substance as an integral component, are placed via image guided catheters into the hepatic artery. The ionizing radiation is directly delivered to the tumor. Currently used commercially available microspheres are based on Yttrium 90, a β-emitter, which has been shown to be safe and to produce good clinical results. The technical features of Y90, their applications and their limitations are presented. Image guidance and intraoperative depiction of Yttrium 90 microspheres are restricted, which is currently one of the main limitations in SIRT. Therapy planning and control is currently based on pre- and post-operative images to evaluate the placement of the microspheres respectively. Holmium 166, another possible nuclide integrated into the microspheres emits a higher amount of secondary γ-radiation (Bremsstrahlung) than Yttrium 90. This enables an improved depiction of the microspheres inside the patient during and immediately after application, but comes with other shortfalls. Imaging of delivery and verification of the microsphere placement could solve many of the identified problems with SIRT. The different technologies are reviewed and an outlook in future developments is given particularly on image guidance and therapy control.