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Bae, M.A., Pie, J.E. and Song, B.J. (2001) Acetaminophen Induces Apoptosis of C6 Glioma Cells by Activating the c-Jun NH(2)-Terminal Protein Kinase-Related Cell Death Pathway. Molecular Pharmacology, 60, 847-856.

has been cited by the following article:

• TITLE: F-Actin Distribution Changes Provoked by Acetaminophen in the Proximal Tubule in Kidney of Adult Male Rat

  AUTHORS: Fernando Jaramillo-Juárez, Jose Roberto Macías-Pérez, Ma. Consolación Martínez-Saldaña, Francisco Javier Avelar-González, Víctor Manuel Loera-Muro, Edgar Eduardo Hernández-Cuéllar, Francisco Jaramillo, Higinio Manuel González Reynaga, Alma Lilian Guerrero-Barrera

  KEYWORDS: Acetaminophen, Cytoskeleton, Proximal Tubule, Kidney Damage

  JOURNAL NAME: Microscopy Research, Vol.4 No.3, July 12, 2016

  ABSTRACT: Acetaminophen is a drug used to treat many conditions as headache, muscle aches, arthritis, backache, toothache, and fever between others, but collateral effects of this drug are not well known yet. Here is tested its effect on proximal tubule epithelium. Acetaminophen (APAP) at doses of 200, 500, 1000 and 1500 mg/Kg i.p. caused cell damage and changes in F-actin distribution in the proximal tubule of male Wistar rats. After 48 hours of treatment, the proximal tubule epithelium showed tumefaction and necrosis. Dose of 200 mg/kg decreased the F-actin and was observed a structure in patches in the basal cytoplasm of epithelial cells of the proximal tubule. This effect was increased depending on the administered dose. Dose of 1000 mg/kg produced the highest histological damage and changes in the actin cytoskeleton. Results of this study suggested that nephrotoxic damage produced by high doses of APAP included breakdown of cytoskeleton in proximal tubule epithelium.