TITLE:
Role of the Metabolic Minor Components in the Regulation of Intermolecular Interaction
AUTHORS:
Frida Gilmiyarova, Nataliya Kolotyeva, Viktoriya Radomskaya, Oksana Gusyakova, Irina Gorbacheva, Valeriya Potekhina
KEYWORDS:
Molecular Modeling, ABO Blood Group System, Lactate, Pyruvate, Intermolecular Interaction
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.4 No.7,
July
8,
2016
ABSTRACT: This work presents
a study of intermolecular interactions using the model of the antigen antibody
interactions of the ABO system. Absence of knowledge in the field of the ABO
antigen’s behavior as a biomolecule and the integration of these structures
into cascade of metabolic and physiological processes create the conditions,
which promote a successful using this new model in the future. Molecular
recognition and designing are included into the main catalog of computer
methods of research, which is called “in
silico”. Using PASS system, we describe the possible biological effects of
pyruvate, lactate, antigen determinants A and B. Pharmacological effects and
molecular mechanisms of influence on activity of the factors regulating inside and
intercellular interactions are predicted for such minor components as pyruvate
and lactate. Due to variety of the biological effects, glycoproteins A and B
are very perspective to study as biological active connections. The obtained
knowledge proves that AB0 antigens, as well as other glycoprotein conjugates
are important mediators of intercellular adhesion and participants of signal
transmission. Using ABO blood group system as a model helped to describe individual
differences of parameters—degree and time of the
agglutination beginning of antigen/antibody blood types of the AB0—are revealed.