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Romestaing, P., Lehingue, Y., Carrie, C., Coquard, R., Montbarbon, X., Ardiet, J.M., Mamelle, N. and Gérard, J.P. (1997) Role of a 10-Gy Boost in the Conservative Treatment of Early Breast Cancer: Result of a Randomized Trial in Lyon, France. Journal of Clinical Oncology, 15, 963-968.

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• TITLE: Quantitative Assessment of Chronic Skin Reactions Including Erythema and Pigmentation after Breast Conserving Therapy

  AUTHORS: Miho Kawashima, Miwako Nozaki, Kazuhiro Komazaki, Ryuko Yamamuro, Kazuo Ishizuna, Makoto Kojima

  KEYWORDS: Breast Cancer, Erythema Index, Melanin Index, Breast-Conserving Therapy

  JOURNAL NAME: Advances in Breast Cancer Research, Vol.5 No.3, July 8, 2016

  ABSTRACT: Purpose: To evaluate long-term skin reactions following breast-conserving therapy by using the melanin-erythema index meter. Patients and Methods: 164 patients were followed for at least three years after breast-conserving therapy. For both the erythema and the melanin indices, the ratio of the irradiated-side index to the non-irradiated-side index was calculated. The time course of index ratios alternation was examined. Influences from additional therapies and patients’ age were also evaluated. Result: Both erythema and melanin index ratios of the breast skin were recovered to pre-radiation level three years after radiotherapy. However, both index ratios of the area administrated with 10-Gy boost irradiation were still high even after five years after radiotherapy. Endocrine therapy, chemotherapy and age had no significant influence on skin color reactions three years after radiotherapy. Conclusion: Quantitative assessment using the melanin-erythema index meter demonstrated that chronic skin reactions following breast conserving therapy had recovered to pre-radiation level for three years after irradiation except for the 10-Gy boost irradiated area.