Article citationsMore>>

S. J. Baker, Y.-K. Zhang, T. Akama, A. Lau, H. Zhou, V. Hernandez, W. Mao, M. R. K. Alley, V. Sanders and J. J. Plattner, “Discovery of a New Boron-Containing Antifungal Agent,” Fluoro-1,3-dihydro-1-hydroxy-2,1-ben-zoxaborole (AN2690), for the potential treatment of onychomycosis,” Journal of Medicinal Chemistry, Vol. 49, No. 15, 2006, pp. 4447-4450. doi:10.1021/jm0603724

has been cited by the following article:

• TITLE: Bioengineering Functional Copolymers. XVII. Interaction of Organoboron Amide-Ester Branched Derivatives of Poly(Acrylic Acid) with Cancer Cells

  AUTHORS: Mustafa Türk, Gülten Kahraman, Sevda A. Khalilova, Zakir M. O. Rzayev, Serpil Oguztüzün

  KEYWORDS: Synthesis, Amidolysis, Organoboron Polymers, Conjugation, Citotoxicity, Apoptotic and Necrotic Effects

  JOURNAL NAME: Journal of Cancer Therapy, Vol.2 No.2, June 29, 2011

  ABSTRACT: Novel bioengineering functional organoboron polymers were synthesized by 1) amidolysis of poly(acrcylic acid) (PAA) with 2-aminoethyldiphenyl borinate (2-AEPB), 2) esterification of organoboron PAA polymer (PAA-B) with a-hydroxy-methoxypoly(ethylene oxide) (PEO) as a compatibilizer and 3) conjugation of organoboron PEO branches (PAA-B-PEO) with folic acid (FA) as a targeting agent. Structure and composition of the synthesized polymers were characterized by FTIR-ATR and 1H (13C) NMR spectroscopy, chemical and physical analysis methods. Anti-tumor activity of organoboron functional polymer and its complex with FA (PAA-B-PEO-F) against cancer and normal cells were evaluated by using different biochemical methods such as cytotoxicity, statistical, apoptotic and necrotic cell indexes, double staining and caspase-3 immune staining, light and fluorescence inverted microscope analyses. It was found that citotoxicity and apoptotic/necrotic effects of polymers significantly depend on the structure and composition of studied polymers, and increase the following raw: PAA