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S. J. Benkovic, S. J. Baker, M. R. K. Alley, Y.-H. Woo, Y.-K. Zhang, T. Akama, W. Mao, J. Baboval, P. T. Ravi Rajagopalan, W. Wall, L. S. Kahng, A.Tavassoli and L. Shapiro, “Identitication of Borinic Esters as Inhibitors of Bacterial Cell Growth and Bacterial Methyltransferases, CcrM and MenH,” Journal of Medicinal Chemistry, Vol. 48, No. 23, 2005, pp. 7468-7476. doi:10.1021/jm050676a

has been cited by the following article:

• TITLE: Bioengineering Functional Copolymers. XVII. Interaction of Organoboron Amide-Ester Branched Derivatives of Poly(Acrylic Acid) with Cancer Cells

  AUTHORS: Mustafa Türk, Gülten Kahraman, Sevda A. Khalilova, Zakir M. O. Rzayev, Serpil Oguztüzün

  KEYWORDS: Synthesis, Amidolysis, Organoboron Polymers, Conjugation, Citotoxicity, Apoptotic and Necrotic Effects

  JOURNAL NAME: Journal of Cancer Therapy, Vol.2 No.2, June 29, 2011

  ABSTRACT: Novel bioengineering functional organoboron polymers were synthesized by 1) amidolysis of poly(acrcylic acid) (PAA) with 2-aminoethyldiphenyl borinate (2-AEPB), 2) esterification of organoboron PAA polymer (PAA-B) with a-hydroxy-methoxypoly(ethylene oxide) (PEO) as a compatibilizer and 3) conjugation of organoboron PEO branches (PAA-B-PEO) with folic acid (FA) as a targeting agent. Structure and composition of the synthesized polymers were characterized by FTIR-ATR and 1H (13C) NMR spectroscopy, chemical and physical analysis methods. Anti-tumor activity of organoboron functional polymer and its complex with FA (PAA-B-PEO-F) against cancer and normal cells were evaluated by using different biochemical methods such as cytotoxicity, statistical, apoptotic and necrotic cell indexes, double staining and caspase-3 immune staining, light and fluorescence inverted microscope analyses. It was found that citotoxicity and apoptotic/necrotic effects of polymers significantly depend on the structure and composition of studied polymers, and increase the following raw: PAA