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Stevens, D.R., Seifert, R., Bufe, B., Müller, F., Kremmer, E., et al. (2001) Hyperpolarization-Activated Channels HC- N1 and HCN4 Mediate Responses to Sour Stimuli. Nature, 413, 631-635.
http://dx.doi.org/10.1038/35098087

has been cited by the following article:

• TITLE: Electrophysiology of Sodium Receptors in Taste Cells

  AUTHORS: Albertino Bigiani

  KEYWORDS: Sodium Taste, Epithelial Sodium Channel, Patch-Clamp Recording

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.9 No.8, June 30, 2016

  ABSTRACT: Sodium intake is important to maintain proper osmolarity and volume of extracellular fluid in vertebrates. The ability to find sources of sodium ions for managing electrolyte homeostasis relies on the activity of the taste system to sense salt. Several studies have been performed to understand the mechanisms underlying Na+ reception in taste cells, the peripheral detectors for food chemicals. It is now generally accepted that Na+ interacts with specific ion channels in taste cell membrane, called sodium receptors. As ion channels, these proteins mediate transmembrane ion fluxes (that is, electrical currents) during their operation. Thus, a lot of information on the functional properties of sodium receptors has been obtained by using electrophysiological techniques. Here, I review our current knowledge on the biophysical and physiological features of these receptors obtained by applying the patch-clamp recording techniques to single taste cells.