TITLE:
A Case Report of Multiple Cylindroma with Immunohistochemical Features
AUTHORS:
Naoki Watanabe, Kana Kawase, Chisato Tawada, Kazufumi Yoneda, Kuniaki Hirai, Ayumi Niwa, Takuji Tanaka
KEYWORDS:
Multiple Cylindroma, Immunohistochemistry, CYLD, NF-κB
JOURNAL NAME:
Open Journal of Pathology,
Vol.6 No.3,
June
29,
2016
ABSTRACT: Cylindroma is a benign skin appendageal
tumor arising from pluripotent stem cells in the follicle. Multiple cylindroma
typically occurs as a component of Brooke-Spiegler syndrome or as the only skin
lesion of familial cylindromatosis. We herein report an unusual case of
multiple cylindroma involving the trunk without any other features of
Brooke-Spiegler syndrome and no family history supporting the possibility of
familial cylindromatosis. Immunohistochemical features of CYLD and NF-κB, which
are involved in the pathogenesis of cylindroma, in the tumors are also
presented.