TITLE:
Sonodynamic Antitumor Effect of Benzoporphyrin Derivative Monoacid Ring A on KLN205 Cells
AUTHORS:
Tomohiro Osaki, Motoshi Tajima, Yoshiharu Okamoto, Satoshi Takagi, Takeshi Tsuka, Tomohiro Imagawa, Saburo Minami
KEYWORDS:
BPD-MA, Cell Damage, Sonodynamic Therapy, Sonosensitizer, Ultrasound
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.2 No.2,
June
29,
2011
ABSTRACT: Sonodynamic therapy is a new cancer treatment based on the synergetic effect of ultrasound and a drug. In this study, ultrasonically induced antitumor effects of benzoporphyrin derivative monoacid ring A (BPD-MA) on KLN205 cells were investigated. KLN205 cells were irradiated at an ultrasonic frequency of 3 MHz with 10 μg/ml BPD-MA. The ultrasonically induced cell damage significantly increased as an ultrasonic intensity and ultrasound exposure time increased. Confocal microscopic examination revealed that the irradiated cells were induced chromatin condensation and phosphatidylserine exposure. The synergistic effect of the ultrasound exposure and BPD-MA on the tumor cell adhesion rate was significant.