TITLE:
Isoforskolin from Native Plant Coleus forskohlii of Yunnan, China Plays Multiple Biological Roles
AUTHORS:
Shi Feng, Ling Wang, Supayang P. Voravuthikunchai, Zhang Liang, Aihua Liu, Fukai Bao
KEYWORDS:
Coleus forskohlii, Natural Compound, Isoforskolin, Bioactivity
JOURNAL NAME:
Open Journal of Immunology,
Vol.6 No.2,
June
23,
2016
ABSTRACT: Isoforskolin (ISOF) was isolated from Coleus forskohlii native to Yunnan in China. It is identified as
one analog of diterpene forskolin (FSK) which comes from the Indian plant Coleus forskohlii. Researches
found that the Yunnan native plant Coleus forskohlii contained rich ISOF but not FSK. ISOF
was reported to activate adenylyl cyclase (AC) isoforms. The ophthalmologic and cardiovascular
effects of ISOF were firstly reported in the 1990s. The researchers in Kunming, China, found ISOF
could lower blood pressure and intraocular pressure. Recent researches found the respiratory
tract effects of ISOF, and showed that ISOF significantly elevated cyclic adenosine monophosphate
(cAMP) levels in rat lung homogenate, and relaxed the histamine-induced contraction of isolated
guinea pig trachea and lung smooth muscle, isoforskolin pretreatment attenuates acute lung injury
induced by lipopolysaccharide (LPS) in several models, lowered LPS-induced secretion of the
inflammatory cytokine in human monocytes.