TITLE:
Concomitant Boost Radiotherapy after Conservative Breast Surgery in Early Breast Cancer
AUTHORS:
Hend Ahmed El-Hadaad, Hanan Ahmed Wahba, Waleed Elnahas, Sameh Roshdy
KEYWORDS:
Conservative Breast Surgery, Radiotherapy, Concomitant Boost, Breast Cancer
JOURNAL NAME:
Advances in Breast Cancer Research,
Vol.5 No.3,
June
21,
2016
ABSTRACT: Background: Radiation
therapy after breast conserving surgery is a standard part of treatment for invasive
breast cancer. Based on radiobiological models, it was found that shorter radiation
schedules offered the promise of equivalent local control to standard radiation
therapy by giving larger doses per fraction in shorter period of time. Methods:
This study included 36 female patients with operable invasive stage I-II breast
cancer. These patients underwent microscopic wide local excision of the primary
tumor and lymph node dissection. They received adjuvant radiotherapy. The radiation
dose was 40 Gy total dose in 15 fractions for whole breast and additional dose of
9 Gy in three consecutive fractions was delivered to tumour cavity simultaneously.
Results: Mean age was 52 years (range: 30 - 67); most patients were of stage II
disease and Grade II was the most common one. Invasive ductal carcinoma was reported
in 94.4% and 72.2% of patients were hormone receptor positive. After median follow-up
of 52 months, all patients were alive and ipsilateral local recurrence was reported
in 1 case only. Grade IV radiation toxicity was not observed; moist desquamation
was the most common acute reaction (61%) with grade III in 5.5% followed by dry
desquamation in 55.6% of grade I only. Grade I erythema was recorded in 41.7% and
grade II in 11%. Fibrosis was the most frequent late reaction (44.3%) with grade
II in 11% followed by telengectesia then pigmentation (41.7%, 33.3% respectively).
Conclusion: The regimen used in this study appears promising with acceptable acute
toxicities and convenient for our patients and has the advantage of economic use
of radiation facilities. However, larger number of patients and longer period of
follow-up are needed for further evaluation.