TITLE:
Neuroprotective Effect of Phyllanthus acidus L. on Learning and Memory Impairment in Scopolamine-Induced Animal Model of Dementia and Oxidative Stress: Natural Wonder for Regulating the Development and Progression of Alzheimer’s Disease
AUTHORS:
Md. Sahab Uddin, Abdullah Al Mamun, Md. Saddam Hossain, Muhammad Ashaduzzaman, Md. Ali Asif Noor, Md. Sarwar Hossain, Md. Josim Uddin, Jyotirmoy Sarker, Md. Asaduzzaman
KEYWORDS:
Neuroprotective, Phyllanthus acidus, Antioxidant Enzyme, Dementia, Oxidative Stress, Acetylcholinesterase Activity, Alzheimer’s Disease
JOURNAL NAME:
Advances in Alzheimer's Disease,
Vol.5 No.2,
June
16,
2016
ABSTRACT: Nature is the best source of complementary and alternative medicine. The plant Phyllanthus acidus (PA) L. has been used traditionally in pain, inflammatory and oxidative stress related disorders. In this consequence, methanolic extract of PA (MEPA) was selected to explore the ability of this plant to enhance cognitive function, brain antioxidant enzymes and anti-acetylcholinesterase activity which can be used for the treatment of oxidative stress related disorders like Alzheimer’s disease (AD). The purpose of this study was to investigate the neuroprotective effect of MEPA on learning and memory impairment in scopolamine-induced rats of dementia and oxidative stress. Treatment with MEPA (i.e., 100 and 200 mg/kg b.w.) was investigated in scopolamine-treated Swiss albino male rats for 14 days and its neuroprotective effects were examined using Elevated Plus Maze (EPM) test, Passive Avoidance (PA) test, Novel Object Recognition (NOR) test, Morris Water Maze (MWM) test as well as level of antioxidant enzymes such as catalase (CAT), super oxide dismutase (SOD), glutathione reductase (GSR), glutathione-S-transferase (GST), reduced glutathione (GSH), glutathione peroxidase (GSH-Px), lipid peroxidation (TBARS) contents and acetylcholinesterase (AChE) activity in rat brain tissue homogenates. Administration of MEPA significantly (P th and 14th day compared to the disease control and control group in the EPM test. In PA test the doses of MEPA suggestively (P th and 14th day with respect to disease control and control group. For NOR test administration of MEPA considerably (P