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Hogeveen, K.N., Cousin, P., Pugeat, M., Dewailly, D., Soudan, B. and Hammond, G.L. (2002) Human Sex Hormone-Binding Globulin Variants Associated with Hyperandrogenism and Ovarian Dysfunction. Journal of Clinical Investigation, 109, 973-981.
http://dx.doi.org/10.1172/JCI0214060

has been cited by the following article:

• TITLE: Sex Hormone Binding Globulin as a Predictor of in Vitro Fertilization Outcomes in Polycystic Ovary Syndrome: Our Results

  AUTHORS: Gaddas Meriem, Chaouache Nesrine, Ajina Mounir, Tabka Zouhair, Zaouali Ajina Monia

  KEYWORDS: SOPK, FIV, SHBG

  JOURNAL NAME: Open Journal of Obstetrics and Gynecology, Vol.6 No.7, June 13, 2016

  ABSTRACT: Objectives: in case of Polycystic Ovary Syndrome (SOPK), predicting ovarian response before undertaking risky in vitro fertilization (IVF) proceeds is crucial. Sex Hormone Binding Globulin (SHBG) is introduced in literature as an interesting indicator of follicle’s maturation and quality. The aim of this study was to investigate whether serum SHBG levels are related to fertilization outcomes in SOPK women undergoing IVF procedures. Methods: in a prospective cohort study, we enrolled 61 SOPK women and 91 matched group of infertile women. All of them were undergoing FIV/ICSI proceeds. SHBG levels were performed in peripheral blood samples as well as others hormones determination. Results: we noted significant differences between our study group of SOPK patients and the Control group concerning the characteristics of the ovarian response to gonadotrophins administration and concerning the profile of biological proceeds’ outcomes. But no significant correlation between SHBG and FIV/ICSI outcomes was found either in SOPK or in Control group. Conclusions: our study provides evidence that SHBG can’t be considered as a predictor of IVF outcomes because production of this steroid-binding protein depends on many parameters such as metabolic disorders frequently associated with SOPK.