Article citationsMore>>
Fukuda, K., Straus, S.E., Hickie, I., Sharpe, M.C., Dobbins, J.G. and Komaroff, A. (1994) The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study. Annals of Internal Medicine, 121, 953-959.
http://dx.doi.org/10.7326/0003-4819-121-12-199412150-00009
has been cited by the following article:
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TITLE:
Persistent Burnout Theory of Chronic Fatigue Syndrome
AUTHORS:
David Jameson
KEYWORDS:
CFS, Burnout, Fatigue, HPA Axis
JOURNAL NAME:
Neuroscience and Medicine,
Vol.7 No.2,
June
8,
2016
ABSTRACT: There is no agreement on the etiology of chronic fatigue syndrome (CFS), and the main theories (behavioural and viral/immune) do not satisfactorily explain the condition. A growing body of evidence suggests that CFS may be caused by a dysfunction of the stress system—and the hypothalamic-pituitary-adrenal (HPA) axis in particular—as a result of chronic stress. CFS shares many similarities to occupational burnout, including similar symptoms, physiological abnormalities and triggers. After a brief review of the science of stress, burnout, central fatigue and CFS, I propose a model of CFS based on a state of persistent burnout that remains after the initial stressors have been removed. This persistence may be due to a combination of a dysregulation of the HPA axis, and behavioural factors. A novel treatment approach based on self-efficacy and positive goals is proposed.