TITLE:
The Mechanism of Cornus officinalis Total Glycosides and Cornus Polysaccharide on Myocardial Protection in Rats with Acute Myocardial Infarction
AUTHORS:
Ke Chen, Jianjun Li, Kefang Chen, Xiangping Hou, Huachao Mai, Xiaojin Xue
KEYWORDS:
Cornus officinalis Total Glycosides, Cornus Polysaccharide, Acute Myocardial Infarction, Glycogen Synthase Kinase 3 Beta
JOURNAL NAME:
Chinese Medicine,
Vol.7 No.2,
June
7,
2016
ABSTRACT: Objective: To
investigate effects of Cornus officinalis Total Glycosides (COTG) and Cornus Polysaccharide (CP) on myocardial protection
and on expression of mitochondria biogenesis related gene of acute myocardial
infarction (AMI) rats, Materials and Methods: Ninety-six SD rats of SPF level were
randomly divided into 5 groups: sham operation group, model group, preventive
treatment group, COTG treatment group, CP treatment group, and there were 12
cases in each one. By legating the left anterior descending branch of coronary
artery method, acute myocardial infarction model was established. The rat of sham
operation group and model group was intragastric administered with physiological
saline; other groups were given with corresponding drugs. The cardiac function,
the myocardial infarct area, the expression of mitochondrial biogenesis genes
such as PGC-1α, PGC-1β, NRF-1mRNA and GSK-3β mRNA, GSK-3β Protein Expression were analyzed. Results: The results revealed
that compared with model group, myocardial infarction size, LVDs, LVDd, LVESV, LVEDP,
and -dp/dt decreased; LVSP increased in preventive
treatment group, COTG treatment group, and CP treatment group (p Cornus officinalis total glycosides
and Cornus polysaccharides can effectively protect myocardial mitochondria of
acute myocardial infarction rats by activating GSK-3β signaling pathways, and reduce the myocardial infarct size, which
has great significance for improving cardiac function.