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Broekhoven, L.H. and Nestmann, E.R. (1991) Statistical Analysis of the Salmonella Mutagenicity Assay. In: Krewski, D. and Franklin, C, Eds., Statistics in Toxicology, Gordon & Breach, Amsterdam, 28-34.

has been cited by the following article:

• TITLE: Antimutagenic and DNA Damage Protective Activities of a Grape Extract from Vitis vinifera

  AUTHORS: Zuzana Rybková, Kateřina Malachová, Jiří Červeň, Hana Sezimová, Petr Pečinka

  KEYWORDS: Ames Test, Antimutagenicity, Free Radical Scavenging, DNA Strand Scission, Vitis vinifera

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.4 No.6, May 24, 2016

  ABSTRACT: Antimutagenic and DNA protective effect of an extract VinOserae from Vitis vinifera grapes on oxidative DNA damage was investigated. The extract’s ability to inhibit mutagenicity induced by tert-butyl hydroperoxide (t-BHP) and hydrogen peroxide (H2O2) was determined with Ames test using Salmonella typhimurium His? TA102 strain. Inhibition values of 44.2% and 67.0% were detected for t-BHP and H2O2, respectively. A protective ability of the extract against DNA strand scission induced by hydroxyl radicals was studied with plasmid pBluescript II SK(-). The analysis of DNA strand breaks in plasmid DNA showed a significant inhibition of DNA damage.