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Verhagen, H., Rompelberg, C.J.M., Strube, M., Van Poppel, G. and Van Bladeren, P.J. (1997) Cancer Prevention by Dietary Constituents in Toxicological Perspective. Journal of Environmental Pathology, Toxicology and Oncology, 16, 343-360.

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• TITLE: Antimutagenic and DNA Damage Protective Activities of a Grape Extract from Vitis vinifera

  AUTHORS: Zuzana Rybková, Kateřina Malachová, Jiří Červeň, Hana Sezimová, Petr Pečinka

  KEYWORDS: Ames Test, Antimutagenicity, Free Radical Scavenging, DNA Strand Scission, Vitis vinifera

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.4 No.6, May 24, 2016

  ABSTRACT: Antimutagenic and DNA protective effect of an extract VinOserae from Vitis vinifera grapes on oxidative DNA damage was investigated. The extract’s ability to inhibit mutagenicity induced by tert-butyl hydroperoxide (t-BHP) and hydrogen peroxide (H2O2) was determined with Ames test using Salmonella typhimurium His? TA102 strain. Inhibition values of 44.2% and 67.0% were detected for t-BHP and H2O2, respectively. A protective ability of the extract against DNA strand scission induced by hydroxyl radicals was studied with plasmid pBluescript II SK(-). The analysis of DNA strand breaks in plasmid DNA showed a significant inhibition of DNA damage.