TITLE:
Diabetes Developing Diagram
AUTHORS:
Nuredin Bakhtiari
KEYWORDS:
Diabetes, Na+-K+ Pump, PGC-1α, AMPK
JOURNAL NAME:
Journal of Biomedical Science and Engineering,
Vol.9 No.6,
May
20,
2016
ABSTRACT: Diabetes mellitus is a metabolic disorder that the cells cannot uptake and use glucose as a source of energy. Many dysfunctions in mitochondria biogenesis/activity and some glycolysis enzymes in diabetic patients have been reported. The aim of this mini-review is to elucidate the cross-talk between signaling pathway which involved in developing of diabetes. Here, there are a related, documented reasons and evidences which investigate energy deficiency in this disease. It seems that a cascade of signaling such as transcription factors (MEF2, CREB, NFAT, P38, MAPK, AMPK) co-activators (PGC-1α) such as calcium ion, protein dependent calcium(CAMK, calcineurine) and Na+-K+ pump have a main role in cell energy regulation. Any dysfunction in these factors can develop diabetes and here, Na+-K+ pump is known as a start point of this diagram.