Article citationsMore>>

Michael, L.F., Wu, Z., Cheatham, R.B., Puigserver, P. and Adelmant, G. (2001) Restoration of Insulin-Sensitive Glucose Transporter (GLUT4) Gene Expression in Muscle Cells by the Transcriptional Coactivator PGC-1. Proc Natl Acad Sci USA, 98, 3820-3825.
http://dx.doi.org/10.1073/pnas.061035098

has been cited by the following article:

• TITLE: Diabetes Developing Diagram

  AUTHORS: Nuredin Bakhtiari

  KEYWORDS: Diabetes, Na+-K+ Pump, PGC-1α, AMPK

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.9 No.6, May 20, 2016

  ABSTRACT: Diabetes mellitus is a metabolic disorder that the cells cannot uptake and use glucose as a source of energy. Many dysfunctions in mitochondria biogenesis/activity and some glycolysis enzymes in diabetic patients have been reported. The aim of this mini-review is to elucidate the cross-talk between signaling pathway which involved in developing of diabetes. Here, there are a related, documented reasons and evidences which investigate energy deficiency in this disease. It seems that a cascade of signaling such as transcription factors (MEF2, CREB, NFAT, P38, MAPK, AMPK) co-activators (PGC-1α) such as calcium ion, protein dependent calcium(CAMK, calcineurine) and Na+-K+ pump have a main role in cell energy regulation. Any dysfunction in these factors can develop diabetes and here, Na+-K+ pump is known as a start point of this diagram.