TITLE:
A New Schiff Base Derivatives Designed to Bind Metal Ion (Cu, Co): Thermodynamics and Biological Activity Studies
AUTHORS:
Hanaa Hameed Haddad
KEYWORDS:
Schiff Base Derivatives, Complexes, Thermodynamic Parameters, FTIR-Spectra, Mole Ratio Method, CHN Analysis, Biological Activity Studies
JOURNAL NAME:
American Journal of Analytical Chemistry,
Vol.7 No.5,
May
13,
2016
ABSTRACT: Schiff base
synthesis is usually acid catalyzed and it usually requires refluxing the
mixture of aldehydes and amine in ethanolic solution. Synthesis and
characterization of Schiff base ligands derived from substituted amine and
salicylaldehyde and their complexes (Cu2+, Co2+) are
reported. The ligands and ligand-complexes were characterized by melting point,
FTIR, CHN-elemental analysis and UV-Visible analysis. The UV-Visible and
elemental analysis of complexes established (1:2) mole ratio (M:L). The
stability constant and thermodynamic parameters (K, ΔG, ΔH, ΔS) were determined
at different temperature (30 - 40)°C which established that the metal-complexes
were very stable. The review describes the promising biological activities
of Schiff base and their metal complexes.